Luciano was no ordinary pharmacist. On March 1889, at the age of 26, he graduated with honors from the University of Santo Tomas with the degree of Licentiate in Pharmacy. Owner of the Botica Luciano on Real Street in Cavite, he had perfected his formula for rare perfumes and lotions, and was awarded a certificate of merit by the Scientific Society of Brussels in Belgium. In recognition of his pioneering activities in the field of Colegio de Farma ceuticos de Manila, a distinction few pharmacists achieved in his time.

Like many sincere and honest intellectuals in countries reeling under foreign domination, Luciano became sensitive to abuses by the alien rulers of the land. He was outspoken in his attitude toward the Spaniards, especially the friars. Consequently, he became one of the cabecillas (little leaders) of the planned uprising in Cavite. A Freemason and a Katipunero, he allowed his drugstore to be the secret connection with the revolutionists in the Bicol region, especially with leader Domingo Abella, one of three Abellas among the Fifteen Martyrs of Bicolandia. Luciano supplied them with medicine and arms.

Barangay Luciano was first named Bitangan, and it was a major source of Bibingka during the hay days. The reason it was one is the location of the old marketplace in Trece Martires City.

As in the profession of its namesake, Barangay Luciano has been a center for health as it became the venue for the then Andres Bonifacio Hospital (now General Emilio Aguinaldo Memorial Hospital) and the Cavite Center for Mental Health.

Based on the historical research, most of the residents, mainly traced their roots from nearby municipalities likes the Diloys, Crucillos, Villas, Guevarras, Feranils from Kayquit, Indang; Roguels and Tejedors from Lumampong, Indang; Espinelis and Roms from Tambo, Indang; Torres form Poblacion, Indang; Costelo from Pangil, Amadeo, Matels and Gutierrezes from Capipisa, Tanza; Lusok from Sahud Ulan, Tanza; Morabes from Salinas, Rosario, Mabituins from Bailen, Belejapas, Salud, Alvarez and Villegas from different places. Most of this migration is due to their employment at the Andres Bonifacio Hospital, Cavite Center for Mental Health and Provincial Capitol.

The Barangay Luciano Hall was first located in the house of then Barangay Treasurer, Felisa Costelo at Crucillo Street. During the 90s it was transferred in J. Villa Street.

Barangay Luciano celebrates its Feast Day on the 28th of October, Saint Jude Thaddeus the Patron Saint of Impossible Cause and Loss Hope. But their Chapel is named Mother of Perpetual Help which the Barangay also commemorate on the 26th of June.